Finally science recognizes how to best use subtle shifts in diet and components of the diet to affect the genes. The goal is to use these subtle shifts in diet by efficacy trials in personalized medicine, also associated with prophylactic or preventative antibiotic therapies. The focus is rapidly moving more to the care and attention to the over prescription of steroids and antibiotics.
Historically prebiotics and probiotics have dominated the microbiome landscape. But now, the new technology focuses on emerging data from numerous labs as the results pertain to the impact of dietary interventions and antibiotic exposure. This approach using nutrition will play formative roles in tailoring therapy to your entire system from the genes and metabolic reaction to the chemistry of how your body responds to food.
What is poised to accomplish this is the new human microbiome project which is the latest project in the media when it comes to science writing about culture and genes. The Human Microbiome Project (HMP), launched by the National Institutes of Health Roadmap for Medical Research, is designed to fuel research into how diet, disease, or drugs change your body which is your internal ecosystem. Check out the HMP site, the “Human Microbiome Project DACC – Home.”
How diet affects your internal ecosystem
Understanding how diet, disease, or drugs affect your internal ecosystem is the goal of the new study. A microbiome is the totality of microbes, their genetic elements (genomes), and environmental interactions in a particular environment. Check out the site, “Home Microbiome Study.” At last the human microbiome project can unite investigators conducting microbiome research in how nutrition influences environmental, agricultural, and biomedical arenas. See the site, “After the human genome project: The human microbiome project.”
And the microbiome project to some extent phases out by more than a decade the excitement over the 2002 human genome project, now that the cost of getting your entire genome tested for health risk and/or ancestry has dropped in cost to around $1,000, making it more affordable. The new microbiomome test on the block is known as the human microbiome project. It’s about the complex ecosystem exists within our bodies — communities of microbes affecting the behavior of human host cells. Read the abstract of the original study, “The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters.”
This crucial “microbiome,” is considered to be a complex “second genome.” The interactions of these microbes and their hosts may yield insights into numerous diseases and disorders. Research in the Federation of American Societies for Experimental Biology (FASEB) Journal discusses designing a protocol for microbiome research ensuring controls for variations among people. Check out the site, “The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters.”
After the human genome project: The human microbiome projectNew research in The FASEB Journal reports the first results of a major scientific effort to understand our own ecosystem: The microbial communities that dwell within us. Earth Day may be more than a month away, but another, more personal, ecosystem has been shown to also be worth protecting—within our bodies are communities of microbes that affect the behavior of human cells hosting them. These communities, called the “microbiome,” are so crucial to our health that some consider it to be a complex “second genome.”Understanding the interaction of these microbes among one another and their human hosts has the potential to yield insights into numerous diseases and complex human disorders from obesity to susceptibility to infection. In a new report appearing in the March 2013 issue of The FASEB Journal, scientists take an important step toward designing a uniform protocol for microbiome research that ensures proper controls and considerations for variations among people.
What you ingest affects your genes along with the rest of your system. By doing this, future researchers should be able to better assess how what we ingest, whether drugs or food, affects our bodies. Check out the site, “Earth Microbiome Project.”
“While historically prebiotics and probiotics have dominated the microbiome landscape, emerging data from numerous labs as to the impact of dietary interventions and antibiotic exposure will play formative roles in tailoring therapy,” explained Kjersti M. Aagaard, M.D., Ph.D., in the February 28, 2013 news release, “After the human genome project: The human microbiome project.” Dr. Aagaard is from the Department of Obstetrics and Gynecology at Baylor College of Medicine in Houston, Texas.
“We may find that the answers to our most common and prevalent health and disease states lies not in manipulating the human genome, but rather, in utilizing subtle shifts in diet and components of the diet, efficacy trials in prophylactic or preventative antibiotic therapies, and care attention to the over prescription of steroids and antibiotics.”
Aagaard and colleagues completed comprehensive body site sampling in healthy 18-40 year old adults, creating an unparalleled reference set of microbiome specimens. Researchers then screened 554 individuals to enroll 300 (149 males, 151 females, mean age 26, mean BMI 24, 20.0 percent racial minority and 10.7 percent Hispanic). See the study’s abstract, “The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters.”
Scientists obtained specimens from several body sites to evaluate the longitudinal changes in an individual’s microbiome by sampling 279 participants twice (mean 212 days after first sampling, range 30-359), and 100 individuals three times (mean 72 days after second sampling, range 30-224). This sampling strategy yielded 11,174 primary specimens, from which 12,479 DNA samples were submitted to four centers for metagenomic sequencing. This clinical design and well-defined reference cohort has laid a baseline foundation for microbiome research. Also see, “Twitter / Search – #microbiome.”
Yogurt, diet soda, or penicillin each alters the microbioal communities that live with you as would other items you eat, breathe, rub on your skin, or inject
“Whether it is yogurt, penicillin, or diet soda, each alters the microbial communities that live within us,” explained Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, in the February 28, 2013 news release. “This pioneering study promises to provide their names and numbers, so that we can understand how diet, disease or drugs affect our internal ecosystem.” Check out how the definition of microbiome is applied, “Microbiome – Wikipedia, the free encyclopedia.”
For further information, check out the original study’s abstract in the March 2013 issue of the FASEB Journal, “The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters.” Authors of the study are Kjersti Aagaard, Joseph Petrosino, Wendy Keitel, Mark Watson, James Katancik, Nathalia Garcia, Shital Patel, Mary Cutting, Tessa Madden, Holli Hamilton, Emily Harris, Dirk Gevers, Gina Simone, Pamela McInnes, and James Versalovic.
The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century. Also see, “Cell Symposia: Microbiome and Host Health: Home.”
FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Its mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and through collaborative advocacy. See the site, “Home Microbiome Study.”
The NIH (government) is involved in the Human Microbiome Project (HMP)
Check out from the National Instistutes of Health (NIH) website what the human microbiome project is about. See the site, “Human Microbiome Project.” The Common Fund’s Human Microbiome Project (HMP) aims to characterize the microbial communities found at several different sites on the human body, including nasal passages, oral cavities, skin, gastrointestinal tract, and urogenital tract, and to analyze the role of these microbes in human health and disease. HMP includes the following initiatives. Also see, “Microbiome journal.”